Calcium for strong clotting

Calcium for strong clotting

alcium fluctuations in the bottom layer of a platelet mass are propagated upwards to determine the size of a blood clot, or thrombus, according to results from Nesbitt et al. presented on page 1151. Platelets adhere to substrates in the vessel wall through receptors such as GPIb and certain integrins. Initial receptor engagement stimulates Ca 2 ϩ spikes in the platelets that lead to firm, perma...

Nomenclature for blood clotting factors.

Clotting revisited

Ancient Greek philosophers extolled moderation in all things. On page 283, Minamoto and colleagues show that carbon monoxide (CO) inhalation is no exception. In a mouse model of trachea transplantation, inhaled CO—in moderation—prevented the development of lethal obstructive airway disease. CO gas is both a toxic air pollutant and a normal byproduct of cellular heme metabolism. Although CO is w...

A Mathematical Model for Blood Clotting

Many biological phenomena are characterized by extensive fluid mechanical and chemical reactionary systems. As such, it is necessary to understand the manner in which these processes develop and the role that they play in a given system. Vascular blood flow is characterized by convective, diffusive, and reactive processes. Specifically, blood clot formation involves platelet convection within t...

Octodon Degus: A Strong Attractor for Alzheimer Research

The most popular animal models of Alzheimer’s disease (AD) are transgenic mice expressing human genes with known mutations which do not represent the most abundant sporadic form of the disease. An increasing number of genetic, vascular and psychosocial data strongly support that the Octodon degus, a moderate-sized and diurnal precocial rodent, provides a naturalistic model for the study of the ...